AMP: 10 Location: WYO 259 and Frontage Rd, Natrona Cty Reassurance shield at the beginning of WYO 259. While WYO 259 is not signed from any direction as the fastest route from Casper to Midwest, it almost certainly is and the road reflects that- it is well built with full shoulders and rumble strips, something … Continue reading Wyoming Highway 259, I-25/US-87 to WYO 387